In the future, automated calculation of CST-lesion load may allow more precise prediction of motor impairment after stroke. Infarct size, despite correlating with motor scores, did not significantly predict impairment.Ĭonclusions- Our results show the degree of functional motor deficit after a stroke is highly dependent on the overlap of the lesion with the CST and not lesion size per se. Results- CST-lesion load was a significant predictor of motor deficit. To analyze the relationship between CST damage and impairment scores, we calculated a CST-lesion load for each patient by overlaying the patient’s lesion map with a probabilistic tract derived from diffusion tensor images of age-matched healthy subjects. We evaluated the degree of motor impairment with the Upper Extremity module of the Fugl-Meyer Assessment. Methods- We studied 50 patients with chronic stroke, all of whom presented with moderate to severe motor impairments in the acute stage, using high-resolution anatomic MRI. In this study, we used lesion-mapping techniques in combination with diffusion tensor imaging to quantitatively test the hypothesis that motor recovery in patients with chronic stroke is inversely related to the proportion of the corticospinal tract (CST) affected by the lesion. Customer Service and Ordering Informationīackground and Purpose- Previous studies have shown motor impairment after a stroke relates to lesion size and location, but unexplained variability in recovery still exists.Stroke: Vascular and Interventional Neurology.
Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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